New Syntheses of Thiamorpholine. The Reduction of Mono-and Diketothiazanes by Lithium Aluminum Hydride

AH Sommers, BW Horrom

Index: Sommers; Horrom Journal of the American Chemical Society, 1954 , vol. 76, p. 1187

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Citation Number: 14

Abstract

Although thiamorpholine is structurally uncomplicated, only two methods for its synthesis have been described1s2 and only three references to its preparation were found in the literature. l-3 These procedures require as starting materials either 2-aminoethyl mercaptan or bis-(2-chloroethyl) sulfide, neither of which is conveniently handled, and the one reported yield is 3070.3 We have prepared thiamorpholine in about 70y0 yield by the reduction of 3 ...