Reaction of acylamino acids with paraformaldehyde

D Ben-Ishai

Index: Ben-Ishai Journal of the American Chemical Society, 1957 , vol. 79, p. 5736

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Citation Number: 78

Abstract

When functional groups other than the amide are and the fact that this intermediate yields sarcosine present in the molecule, intramolecular methylene benzylamide on catalytic hydrogenation strongly bridge formation may occur leading to cyclic prod-supports the N- methylol-N-carbobenzoxyglycine ucts. Thus, asparagine affords, on treatment with benzylamide formulation (VI). formaldehyde, 6-hydroxy-tetrahydro-pyrimidyl-4-dehyde ...