1, 2??Dihydroisoquinoline??N??Acetic Acid Derivatives as New Carriers for Specific Brain Delivery I: Synthesis and Estimation of Oxidation Kinetics Using Multivariate …

S Mahmoud, T Aboul??Fadl, M Sheha…

Index: Mahmoud, Sahar; Aboul-Fadl, Tarek; Sheha, Mahmoud; Farag, Hassan; Mouhamed, Abdel-Maaboud I. Archiv der Pharmazie, 2003 , vol. 336, # 12 p. 573 - 584

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Citation Number: 21

Abstract

Abstract In order to overcome the slow oxidation of 1, 2-dihydro-N-alkylisoquinoline, 1, 2- dihydroisoquinoline-N-acetic acid derivatives (3b—d) were designed and synthesized as new chemical delivery systems (CDS) for the brain. Molecular orbital calculations for the suggested derivatives revealed that these carriers are stable against oxidation. However, hydrolysis to their corresponding anions will accelerate the rate of oxidation, and ...