The synthesis of tetrahydroquinolines related to virantmycin

CL Francis, NM Williamson, AD Ward

Index: Francis, Craig L.; Williamson, Natalie M.; Ward, A. David Synthesis, 2004 , # 16 p. 2685 - 2691

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Citation Number: 8

Abstract

Abstract 4-Substituted anilines react with 1-methoxymethyl-1-butyl-3-trimethysilylpropargyl chloride but not with 1, 1-dibutyl-3-trimethylsilylpropargyl chloride, to form the corresponding substituted N-propargylanilines. These anilines cyclise, using cuprous chloride, in the presence of trifluoroacetic anhydride, and, when the aniline substituent is electron donating, to give 6-substituted 2-butyl-2-methoxymethyl-1-trifluoroacetyl-1, 2-dihydroquinolines. ...