Synthesis of bradykinyl-Val-Ala-Pro-Ala-Ser-OH and its biological properties

N YANAIHARA, C YANAIHARA, M SAKAGAMI…

Index: Yanaihara; Sakagami; Nakajima; Nakayama Chemical and pharmaceutical bulletin, 1973 , vol. 21, # 3 p. 616 - 621

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Citation Number: 11

Abstract

Synthesis is described of bradykinyl-Val-Ala-Pro-Ala-Ser-OH. All the fragment condensations were carried out by Rudinger's azide method in order to minimize the racemization during the coupling steps involving peptide fragments. The ensuing tetradecapeptide with a high degree of homogeneity was found to be identical with bradykinyl-Val-Ala-Pro-Ala-Ser-OH of natural origin with respect to chemical and ...