Alpidem analogues containing a GABA or glycine moiety as new anticonvulsant agents

…, A Latrofa, M Franco, A Carrieri, S Cellamare…

Index: Trapani, Giuseppe; Latrofa, Andrea; Franco, Massimo; Carrieri, Antonio; Cellamare, Saverio; Serra, Mariangela; Sanna, Enrico; Biggio, Giovanni; Liso, Gaetano European Journal of Pharmaceutical Sciences, 2003 , vol. 18, # 3-4 p. 231 - 240

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Citation Number: 11

Abstract

Alpidem analogues containing a GABA (1–3) or glycine (4–6) moiety were synthesized and their interaction with the GABA/benzodiazepine receptor complex at central (CBR) and peripheral (PBR) level was evaluated. In particular, their ability to modulate the specific binding of [3H]-GABA to washed membrane preparations from the rat cerebral cortex, as well as their effects on human recombinant GABAA receptors in Xenopus laevis oocytes, ...