Palladium??Catalyzed C H Oxidation of Isoquinoline N??Oxides: Selective Alkylation with Dialkyl Sulfoxides and Halogenation with Dihalo sulfoxides

…, JH Li, MK Wang, RY Tang, XG Zhang…

Index: Yao, Bo; Song, Ren-Jie; Liu, Yan; Xie, Ye-Xiang; Li, Jin-Heng; Wang, Meng-Ke; Tang, Ri-Yuan; Zhang, Xing-Guo; Deng, Chen-Liang Advanced Synthesis and Catalysis, 2012 , vol. 354, # 10 p. 1890 - 1896

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Citation Number: 30

Abstract

Abstract A novel palladium-catalyzed C [BOND] H oxidation of isoquinoline N-oxides has been developed for regioselectively synthesizing substituted isoquinolines. The method represents the first example of using dialkyl sulfoxides as the alkyl sources for the construction of 1-alkylated isoquinolines. Moreover, the regioselective halogenation of isoquinoline N-oxides is also successful using dihalo sulfoxides as the halide sources.

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