Acidic Ionic Liquid–Catalyzed Highly Efficient Reaction of Indoles to α, β??Unsaturated Ketones

D Gu, S Ji, H Wang, Q Xu

Index: Gu, Da-Gong; Ji, Shun-Jun; Wang, Hong-Xia; Xu, Qiu-Yan Synthetic Communications, 2008 , vol. 38, # 8 p. 1212 - 1223

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Citation Number: 12

Abstract

Abstract A novel method for the Michael reaction of indoles to α, β??unsaturated ketones catalyzed by acidic ionic liquid is reported. We obtained the corresponding products in excellent yields in the presence of [hmim] HSO4. Development of this method has resulted in a new protocol for the synthesis of β??indolylketones.