Tetrahedron letters

New synthetic approaches to estrogen receptor modulators: imidazo [1, 2-a] pyridines

…, JA Linn, DH Drewry, DA Hillesheim, WJ Zuercher…

Index: Patel, Hari S.; Linn, James A.; Drewry, David H.; Hillesheim, Daniel A.; Zuercher, William J.; Hoekstra, William J. Tetrahedron Letters, 2003 , vol. 44, # 21 p. 4077 - 4080

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Citation Number: 16

Abstract

Constrained triarenes have been important templates for selective modulation of the estrogen receptor (ER). For our ER program, we sought an unexplored, synthetically accessible heterocyclic template capable of bearing a broad range of pharmacophores. Traditional approaches to these therapeutics such as raloxifene have relied on an alkoxy moiety to link the arene-based scaffold to the modulating amine group. Alternatively, aryl ...