Tetrahedron letters

Apparent proton-catalyzed Meerwein-Ponndorf-Verley type reduction of 8-chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo [1, 5-a][1, 4] benzodiazepine

K Ramig, MA Kuzemko, D Parrish, BK Carpenter

Index: Ramig; Kuzemko; Parrish; Carpenter Tetrahedron Letters, 1992 , vol. 33, # 42 p. 6279 - 6282

Full Text: HTML

Citation Number: 2

Abstract

Abstract When treated with 2-propanol in the presence of HCl, reduction of the C4-N double bond in 8-chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo [1, 5-a][1, 4] benzodiazepine occurs. Data are presented which indicate 2-propanol is the reductant in a two-step mechanism.