Organic letters

Diazotrifluoropropionamido-containing prenylcysteines: syntheses and applications for studying isoprenoid-protein interactions

TA Kale, MD Distefano

Index: Kale, Tamara A.; Distefano, Mark D. Organic Letters, 2003 , vol. 5, # 5 p. 609 - 612

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Citation Number: 21

Abstract

Photoaffinity-labeled prenylcysteines (1 and 2) incorporating a diazotrifluoropropionamide- based photophore have been prepared. Photolyses of 2 in the presence of RhoGDI, a protein that interacts with prenylated proteins, and prenylcysteine-containing competitors demonstrate the effectiveness of this photoaffinity-labeled analogue as a tool for studying isoprenoid binding sites.