Synthesis, toxicological and pharmacological assessment of some 4-hydroxycoumarin derivatives

I Manolov, ND Danchev

Index: Manolov; Danchev European Journal of Medicinal Chemistry, 1995 , vol. 30, # 6 p. 531 - 535

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Citation Number: 113

Abstract

The synthesis of seven coumarin derivatives from 4-hydroxycoumarin and different unsaturated ketones is described. The structures of the synthesized compounds were proved by IR, 1H-NMR and mass-spectral data. Acute toxicity studies of the compounds were performed on mice by oral and intraperitoneal administration. A comparative pharmacological study of the in vivo anticoagulant effects of the derivatives with respect to ...