2, 2', 4, 5, 5'-Pentachlorobiphenyl: comparative metabolism in mink (Mustela vison) and mouse

E Klasson Wehler, L Hovander…

Index: Wehler, Eva Klasson; Hovander, Lotta; Lund, Bert-Ove Chemical Research in Toxicology, 1996 , vol. 9, # 8 p. 1340 - 1349

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Citation Number: 24

Abstract

The metabolism of 14C-labeled 2, 2', 4, 5, 5'-pentachlorobiphenyl was studied in mink (Mustela vison) and, for comparison, in the mouse (C57Bl). Both species were dosed orally and kept in metabolism cages for 5 days. Distribution in tissues and excretion rate were determined radiometrically, and metabolites were analyzed by GC/MS. Within 5 days, the mink excreted 17% of the dose, and the mouse excreted 74%, mainly via the feces. For ...