Tetrahedron Letters

Total synthesis of resolvin E2

Y Kosaki, N Ogawa, Y Kobayashi

Index: Kosaki, Yusuke; Ogawa, Narihito; Kobayashi, Yuichi Tetrahedron Letters, 2010 , vol. 51, # 14 p. 1856 - 1859

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Citation Number: 17

Abstract

Resolvin E2 (2) was synthesized stereoselectively using the C1–8 and C15–20 aldehydes 6 and 9, which were connected to the C9–14 fragment by using Wittig reactions. The aldehyde 6 was prepared from the γ-silyl alcohol (S)-20 by a sequence of reactions involving ozonolysis, oxidation with NaIO4, and the Wittig reaction of the resulting aldehyde with Ph3PCHCHO, whereas the aldehyde 9 was synthesized from the corresponding γ-silyl ...

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