Aminotetralins as narcotic antagonists. Synthesis and opiate-related activity of 1-phenyl-1-aminotetralin derivatives

WG Reifenrath, DS Fries

Index: Reifenrath,W.G.; Fries,D.S. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 204 - 206

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Citation Number: 5

Abstract

R e conclude that the interaction of amines with photoexcited chlorophenothiazines 1 and 5 contributes to their photoreactivity. However, even in the absence of the side chain, 5 is still decomposed rather efficiently (4= 0.2). This makes it relatively unlikely that a photostable drug of the chlorpromazine family can be synthesized merely by altering the constitution of the side chain of the drug. On photochemical grounds. substitution of the chlorine atom ...