Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R, 2R-dicamphanoyl-3, 3-dimethyldihydropyrano-[2, 3-c] xanthen-7 (1H)-one (DCX) derivatives as novel …
…, CH Chen, L Huang, P Ho, SL Morris-Natschke…
Index: Zhou, Ting; Shi, Qian; Chen, Chin-Ho; Huang, Li; Ho, Phong; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 86 - 96
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Citation Number: 14
Abstract
In this study, 1R, 2R-dicamphanoyl-3, 3-dimethydihydropyrano [2, 3-c] xanthen-7 (1H)-one (DCX) derivatives were designed and synthesized as novel anti-HIV agents against both wild-type and non-nucleoside reverse transcriptase (RT) inhibitor-resistant HIV-1 (RTMDR- 1) strains. Twenty-four DCX analogs (6–29) were synthesized and evaluated against the non-drug-resistant HIV-1 NL4-3 strain, and selected analogs were also screened for their ...
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