Tetrahedron letters

S-2-(2, 4-dinitrophenyl) ethyl-L-cysteine: a new derivative for solid-phase peptide synthesis

…, C García-Echeverría, E Giralt, R Eritja, F Albericio

Index: Royo; Garcia-Echeverria; Giralt; Eritja; Albericio Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2391 - 2394

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Citation Number: 14

Abstract

Abstract A new acid stable protecting group for the sulfhydryl function of cystein is described. The S-2-(2, 4-dinitrophenyl) ethyl-L-cysteine derivative is fully compatible with the Boc/Bzl solid phase peptide synyhesis strategy and can be smoothly and quantitatively removed to give the free thiol or a disulfide bridge.