Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity

…, K Nakagawa-Goto, CY Lai, SL Morris-Natschke…

Index: Dong, Yizhou; Nakagawa-Goto, Kyoko; Lai, Chin-Yu; Morris-Natschke, Susan L.; Bastow, Kenneth F.; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2341 - 2344

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Citation Number: 20

Abstract

4-Amino-2H-benzo [h] chromen-2-one (ABO) and 4-amino-7, 8, 9, 10-tetrahydro-2H-benzo [h] chromen-2-one (ATBO) analogs were found to be significant in vitro anticancer agents in our previous research. Our continuing study has now discovered a new simplified (monocyclic rather than tricyclic) class of cytotoxic agents, 4-amino-2H-pyran-2-one (APO) analogs. By incorporating various substituents on the pyranone ring, we have established ...