Tetrahedron

New routes to substituted tropones

LCA Barbosa, J Mann, PD Wilde, MW Finch

Index: Barbosa, Luiz-Claudio Almeida; Mann, John; Wilde, Philip D.; Finch, Mark W. Tetrahedron, 1989 , vol. 45, # 14 p. 4619 - 4626

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Citation Number: 19

Abstract

In a previous paper1 we described our initial efforts to prepare aryl- substituted tropones. The rationale for this work was the known anti- tumour activity of the aryl-tropolone (1)2, which has some structural resemblance to colchicine (2). In continuation of this work we now describe the synthesis of various 2- and 2,7-disubstituted tropones from readily accessible 8-oxabicycloC3.2.11oct-6-en-3-ones ... Upon reaction of the 2-phenyl-oxabicycle (3)4 ...