Synthesis and characterization of piperazine-2, 6-diones

T Mancilla, L Canillo, LS Zamudio-Rivera…

Index: Mancilla, Teresa; Carrillo, Lourdes; Zamudio-Rivera, Luis S.; Beltran, Hiram I.; Farfan, Norberto Organic Preparations and Procedures International, 2002 , vol. 34, # 1 p. 87 - 94

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Citation Number: 11

Abstract

Piperazinediones also known as diketopiperazines, are the smallest cyclic peptides, as well as a common motif in several natural products with therapeutic properties.'It has been shown that bisdiketopiperazines exhibit antitumor activity against Lewis lung carcinoma, sarcoma 180, L12 10 leukemia, P388 leukemia, B 16 myeloma, malignant lymphoma, C-26 colon, C- 38 human colon and breast cancer. 2-8 They have also been used in clinical trial ...

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