A practical total synthesis of plaunotol via highly Z-selective Wittig olefination of α-acetal ketones 1

K Tago, M Arai, H Kogen

Index: Tago, Keiko; Arai, Masami; Kogen, Hiroshi Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 13 p. 2073 - 2078

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Citation Number: 27

Abstract

Plaunotol (1), a known antiulcer drug, is the most important component of the Thai folk medicinal plant, Plau-noi, which has remarkable antipeptic ulcer activity. Recently, it was found that plaunotol (1) has antibacterial activity against Helicobacter pylori, a causative agent in gastric ulcers and gastric adenocarcinoma, for example. In our investigation of the practical synthesis of 1, we have developed an efficient method for stereoselective ...