Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity

…, D Barrett, H Azami, C Morinaga, Y Matsumoto…

Index: Yoshida, Yoshiki; Barrett, David; Azami, Hidenori; Morinaga, Chizu; Matsumoto, Yoshimi; Takasugi, Hisashi Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 14 p. 1897 - 1902

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Citation Number: 7

Abstract

The synthesis and in vitro optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives discovered by a random screening process, are described. FR180102 (7f), having a 3-acetamido-2, 6-dichlorobenzyl moiety, was found to have extremely potent activity against H. pylori and no effect against a series of common Gram-positive and Gram-negative bacteria.