Synthesis of 2??aminoquinazolinc??4 (3H)??one derivatives as potential potassium channel openers

…, B Rigo, B Pirotte, D Couturier

Index: Erb, Benedicte; Akue, Rufine; Rigo, Benoit; Pirotte, Bernard; Couturier, Daniel Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 253 - 260

Full Text: HTML

Citation Number: 13

Abstract

258 В. Erb, R. Akuc, В. Rigo, В. Pirottc and D. Couturier Vol. 37 Scheme 7 Me f-Bu—¿ + HO-NH2 i-Bi H NOH 20 Me l-Bu 4 NH2 Me f'Bu4 N-OCOMe 19 21 profile of potassium channel openers (data not shown). However, the exact mechanism of action remains to be elucidated. EXPERIMENTAL Melting points are uncorrected. The ir spectra were recorded on a 'Perkin-Elmer' 700 spectrometer and the nmr spectra on a Varian 'Gemini 2000* at 200 MHz for >H and 50 MHz for l3C, ...