A convenient synthesis of 2-cyano-3-substituted indoles

S Denison, ST Hilton

Index: Denison, Sophie; Hilton, Stephen T. Synlett, 2004 , # 15 p. 2806 - 2808

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Citation Number: 5

Abstract

A new and mild method for the synthesis of 2-cyano-3-substituted indoles is described which is effective on N-unsubstituted indoles. ... Substituted cyanoindoles are important intermediates in the synthesis of heteroaromatic molecules and have found some use in the synthesis of biologically active compounds. [2] [3] Incorporation of the nitrile functionality into substituted indoles has been accomplished via a variety of methods which often involve multi-step routes and harsh, ...