Reversible inhibitors of the gastric (H+/K+)-ATPase. 5. Substituted 2, 4-diaminoquinazolines and thienopyrimidines

RJ Ife, TH Brown, P Blurton, DJ Keeling…

Index: Ife, Robert J.; Brown, Thomas H.; Blurton, Peter; Keeling, David J.; Leach, Colin A.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2763 - 2773

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Citation Number: 90

Abstract

Quinazolines bearing a secondary 44arylamino) substituent demonstrate an SAR for inhibition of* the gastric (H+/K+)-ATPase different from the previously described 3- acylquinolines, suggesting that, although these compounds are also Kf-competitive, they probably bind to the enzyme in a different orientation. Compounds bearing a tertiary 44arylamino) substituent, however, in particular 4-(N-methylarylamino), appear to possess ...