European Journal of Organic Chemistry

Reduction of Activated Carbonyl Groups Using Alkylphosphanes as Reducing Agents: A Mechanistic Study

Y Wei, XG Liu, M Shi

Index: Wei, Yin; Liu, Xu-Guang; Shi, Min European Journal of Organic Chemistry, 2012 , # 12 p. 2386 - 2393

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Citation Number: 5

Abstract

Abstract A comprehensive mechanistic investigation on the reduction of activated carbonyl groups using alkylphosphanes as reducing agents has been conducted through a combination of experimental as well as computational studies. Both approaches show that this kind of reduction proceeds either through proton transfer from alkylphosphanes and cleavage by water during work-up or through another reaction pathway involving the ...