α-Trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines

…, H Sakagami, K Kusama, N Motohashi, S Saito

Index: Kawase, Masami; Sakagami, Hiroshi; Kusama, Kaoru; Motohashi, Noboru; Saito, Setsuo Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 21 p. 3113 - 3118

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Citation Number: 32

Abstract

Cytotoxic activity of newly synthesized trifluoromethyl ketones and related compounds was studied using two human oral tumor cell lines (HSG and HSC-2). Among them, α- trifluoromethylacyloins (1 and 2) were found to induce apoptotic cell death, as judged by the terminal deoxynucleotidyl transferase (TdT) dUTP nick end-labeling (TUNEL) method which detects DNA nick or fragments. Furthermore, the cytoplasm of 1 or 2 treated HSG cells was ...