Synthesis and biological activity of 4-(diphenylmethyl)-. alpha.-[(4-quinolinyloxy) methyl]-1-piperazineethanol and related compounds

I Sircar, SJ Haleen, SE Burke…

Index: Sircar, Ila; Haleen, Steve J.; Burke, Sandra E.; Barth, Hubert Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4442 - 4449

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Citation Number: 22

Abstract

A series of 4-(diphenylmethyl)-a-[(4quinolinyloxy) methylhyll-l-piperazineethanol and closely related compounds was synthesized and evaluated for cardiac and vascular activity in isolated perfused rat and guinea pig hearts. Compound 1 produced greater inotropic effects in rat hearts than in guinea pig hearts, a phenomenon which was also observed with the prototype agent DPI 201-106. Compound 15 produced an inotropic effect with one-tenth ...