Synthesis of analogues of the 2-O-alkyl glycerate part of the moenomycins

U Eichelberger, I Neundorf, L Hennig, M Findeisen…

Index: Eichelberger, Uwe; Neundorf, Ines; Hennig, Lothar; Findeisen, Matthias; Giesa, Sabine; Mueller, Dietrich; Welzel, Peter Tetrahedron, 2002 , vol. 58, # 3 p. 545 - 559

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Citation Number: 12

Abstract

The moenomycin antibiotics (see, for example, moenomycin A (1), 1 Scheme 1) are the only compounds known with certainty to inhibit the enzyme of the transglycosylation reaction, 2 one of the last steps in the biosynthesis of peptidoglycan 3 (main component of the bacterial cell wall). A mechanism for their mode of action has been proposed. 4., 5. and 6. It is assumed that they are anchored to the cytoplasmic membrane via the lipid part and bind then highly ...