Synthesis and anti-leishmanial activity of 1-aryl-β-carboline derivatives against Leishmania donovani

…, KG Brahmbhatt, PM Loiseau, KK Bhutani

Index: Gohil, Vikrantsinh M.; Brahmbhatt, Keyur G.; Loiseau, Philippe M.; Bhutani, Kamlesh K. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3905 - 3907

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Citation Number: 14

Abstract

β-carbolines from various natural and synthetic sources have been known to show diverse biological activities. As a part of our current ongoing project to search for potent natural product-derived anti-leishmanial compounds, we have synthesized a series of substituted 1- aryl-β-carboline derivatives. A total of 22 compounds were synthesized and tested in vitro against Leishmania donovani, out of which 6 compounds (4, 5, 10, 11, 19 and 22) showed ...