Prediction of Perception: Probing the hOR17??4 Olfactory Receptor Model with Silicon Analogues of Bourgeonal and Lilial

…, R Bertermann, A Triller, H Hatt, R Tacke

Index: Doszczak, Leszek; Kraft, Philip; Weber, Hans-Peter; Bertermann, Ruediger; Triller, Annika; Hatt, Hanns; Tacke, Reinhold Angewandte Chemie - International Edition, 2007 , vol. 46, # 18 p. 3367 - 3371

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Citation Number: 47

Abstract

The award of the Nobel prize to Axel [1a] and Buck [1b] for their pioneering studies on the mechanism of odor perception generated high expectations concerning the prediction of olfactory properties. This was perhaps unjustified, as Buck et al.[2a] also discovered that each odorant triggers a combination of different receptors, that odors consequently correspond to complex activation patterns of glomeruli, and that mixtures can even ...