RSC Advances

Meso-scale microwave-assisted continuous flow reactions utilizing a selective heating matrix

MJ Karney, KA Porter, EK Barnhardt, GS Vanier

Index: Karney, Michael J.; Porter, Keith A.; Barnhardt, E. Keller; Vanier, Grace S. RSC Advances, 2013 , vol. 3, # 19 p. 7106 - 7111

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Citation Number: 4

Abstract

Convergence of two powerful synthetic tools, microwave heating and flow chemistry, is described herein. Utilizing a selectively heated, microwave absorbing material as part of a packed reactor bed, several chemistries such as N-Boc pyrolysis, Michael additions, and Diels–Alder cycloadditions were performed at elevated temperatures. Scale-up from microwave batch to flow was readily accomplished and results showed that flow greatly ...