Metallation in connection with cross-coupling reactions. Coupling of hindered aryls for the synthesis of 4-phenylpyridines as part of Streptonigrin and Lavendamycin …

…, L Thomas-dit-Dumont, JC Rovera, JF Thaburet…

Index: Godard; Rocca; Pomel; Thomas-Dit-Dumont; Rovera; Thaburet; Marsais; Queguiner Journal of Organometallic Chemistry, 1996 , vol. 517, # 1-2 p. 25 - 36

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Citation Number: 32

Abstract

The synthesis of the C D ring system of Streptonigrin and Lavendamycin alkaloid analogues by cross-coupling under Suzuki's conditions has been studied. Steric hindrance is the main problem. It has been solved either by using strong bases or working in a sealed tube under pressure.