Structure− activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents

…, S Sauvage, M El Yazidi…

Index: Van Quaquebeke, Eric; Mahieu, Tine; Dumont, Patrick; Dewelle, Janique; Ribaucour, Fabrice; Simon, Gentiane; Sauvage, Sebastien; Gaussin, Jean-Francois; Tuti, Jerome; El Yazidi, Mohamed; Van Vynckt, Frank; Mijatovic, Tatjana; Lefranc, Florence; Darro, Francis; Kiss, Robert Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 4122 - 4134

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Citation Number: 97

Abstract

Narciclasine (1) is a plant growth regulator that has been previously demonstrated to be proapoptotic to cancer cells at high concentrations (≥ 1 μM). Data generated in the present study show that narciclasine displays potent antitumor effects in apoptosis-resistant as well as in apoptosis-sensitive cancer cells by impairing the organization of the actin cytoskeleton in cancer cells at concentrations that are not cytotoxic (IC50 values of 30− 90 nM). The ...