Enzymatic synthesis of cyclic amino acids by N-methyl-L-amino acid dehydrogenase from Pseudomonas putida

M Yasuda, M Ueda, H Muramatsu, H Mihara…

Index: Yasuda, Mari; Ueda, Makoto; Muramatsu, Hisashi; Mihara, Hisaaki; Esaki, Nobuyoshi Tetrahedron Asymmetry, 2006 , vol. 17, # 12 p. 1775 - 1779

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Citation Number: 30

Abstract

A new enzymatic system for the synthesis of enantiomerically pure cyclic amino acids (CAA) from the corresponding diamino acids or racemic CAA is described. α, ω-Diamino acids were oxidized to α-keto acids with amino acid oxidases (AAO). The α-keto acids were spontaneously transformed into cyclic imino acids in the reaction medium. The resulting imines were reduced to the l-form CAA with N-methyl-l-amino acid dehydrogenase ( ...

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