Molecules

Original TDAE strategy using propargylic chloride: rapid access to 1, 4-diarylbut-3-ynol derivatives

M Roche, T Terme, P Vanelle

Index: Roche, Manon; Terme, Thierry; Vanelle, Patrice Molecules, 2013 , vol. 18, # 2 p. 1540 - 1548

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Citation Number: 4

Abstract

Abstract We report herein the first synthesis of propargylic alcohols using an organic reducing agent. Diarylbutynol derivatives are formed in moderate to good yields under mild conditions from the reaction of 1-(3-chloroprop-1-ynyl)-4-nitrobenzene with various aromatic aldehydes using tetrakis (dimethylamino) ethylene (TDAE) as reductant. Keywords:

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