Synthesis, structures and anti-malaria activity of some gold (I) phosphine complexes containing seleno-and thiosemicarbazonato ligands

A Molter, J Rust, CW Lehmann, G Deepa, P Chiba…

Index: Molter, Anja; Rust, Joerg; Lehmann, Christian W.; Deepa, Ganesh; Chiba, Peter; Mohr, Fabian Dalton Transactions, 2011 , vol. 40, # 38 p. 9810 - 9820

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Citation Number: 25

Abstract

A series of both mono-and dinuclear gold (I) phosphine complexes containing monoanionic seleno-and thiosemicarbazones as ligands were prepared and fully characterized by spectroscopic methods and, in some cases, by single crystal X-ray diffraction. The in vitro anti-malaria activity of some of these compounds was investigated in chloroquine sensitive strains of Plasmodium falciparum. The IC50 results show that the sulfur containing ...

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