Synthesis of 20-iodoeicosanoic and 20-[125 I]-iodoeicosanoic acids

J Protiva, J Pecka, J Urban, J Zima

Index: Protiva, Jiri; Pecka, Jaroslav; Urban, Jiri; Zima, Jiri Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 6 p. 1546 - 1554

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Abstract

Abstract 20-Iodoeicosanoic acid (X) was prepared in 9 steps, its carbon chain being constructed from thiophene and ethyl ester chlorides of dodecanedioic and butanedioic acids. Isotope exchange afforded 20-[125 I]-iodoeicosanoic acid required for scintigraphic studies of the myocardium. Desulfuration of the thiophene precursor VIII was accompanied by formation of side products XI-XIX arising by cleavage of the thiophene CC bonds. ...