Substituted benz [a] acridines and benz [c] acridines as mammalian topoisomerase poisons

D Makhey, C Yu, A Liu, LF Liu, EJ LaVoie

Index: Makhey, Darshan; Yu, Chiang; Liu, Angela; Liu, Leroy F.; Lavoie, Edmond J. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 5 p. 1171 - 1182

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Citation Number: 37

Abstract

Coralyne and several other synthetic benzo [a, g] quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the presence of a positively charged iminium group, which has been postulated to be associated with their pharmacological properties. The objective of the present study was to devise stable noncharged bioisosteres of these compounds. ...