Synthetic Communications

An Improved Method for γ-Carboxylation of β-Diketones. Synthesis of 4-Alkyl-3, 5-Dioxohexanoic Acids and 5-Alkyl Derivatives of Triacetic Acid Lactone

J Cervelló, J Marquet…

Index: Cervello, Jordi; Marquet, Jorge; Moreno-Manas, Marcial Synthetic Communications, 1990 , vol. 20, # 13 p. 1931 - 1941

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Citation Number: 13

Abstract

Abstract γ-Carboxylation of β-diketones, 1, can be improved using samples containing 100% of ketoenol tautomers, 3, prepared by mild hydrolysis of the corresponding copper (II) complexes 2. Cyclization of the so formed 4-alkyl-3, 5-dioxohexanoic acids, 4, affords 5-alkyl- 4-hydroxy-6-methyl-2-pyrones, 5.