Asymmetric autocatalysis enables an improved synthesis of efavirenz

N Chinkov, A Warm, EM Carreira

Index: Chinkov, Nicka; Warm, Aleksander; Carreira, Erick M. Angewandte Chemie - International Edition, 2011 , vol. 50, # 13 p. 2957 - 2961

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Citation Number: 50

Abstract

Asymmetric alkynylide additions to carbonyls have emerged as a useful tool in organic synthesis.[1] Several different stoichiometric and catalytic versions of additions to aldehydes have been documented for the preparation of secondary propargylic alcohols in high enantiomeric purity.[2] By contrast, enantioselective alkynylation of ketones towards the formation of tertiary alcohols has enjoyed only limited success with respect to both scope ...

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