Tetrahedron letters

The synthesis of (4R-cis)-1, 1-dimethylethyl 6-cyanomethyl-2, 2-dimethyl-1, 3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a highly potent, …

…, DE Butler, CF Deering, TV Le, A Millar, TN Nanninga…

Index: Brower; Butler; Deering; Le; Millar; Nanninga; Roth Tetrahedron Letters, 1992 ,  vol. 33,  # 17  p. 2279 - 2282

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Citation Number: 101

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Three alternative methods for the synthesis of the optically active heptanoate (6), a key intermediate in the preparation of a highly potent and tissue selective HMG Co-A reductase inhibitor are described. ... Several approaches to the synthesis of the optically pure hexanoate 6 have ...