Direct asymmetric hydrogenation of 2-oxo-4-arylbut-3-enoic acids

…, Q Meng, W Fan, X Xie, Z Zhang

Index: Zhu, Lvfeng; Meng, Qinghua; Fan, Weizheng; Xie, Xiaomin; Zhang, Zhaoguo Journal of Organic Chemistry, 2010 ,  vol. 75,  # 17  p. 6027 - 6030

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Citation Number: 18

Abstract

A challenging direct asymmetric hydrogenation of (E)-2-oxo-4-arylbut-3-enoic acids to give 2- hydroxy-4-arylbutanoic acids (85.4− 91.8% ee) was achieved with a Ru catalyst based on SunPhos as the chiral ligand. Further investigation of the reaction revealed that partial isomerization of 2-hydroxy-4-arylbutenoic acids was involved in the hydrogenation process. Employing the reaction conditions to the hydrogenation of 2-oxo-4-phenylbutanoic acid ...