Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2, 4-diamino-5-[2-methoxy-5-(ω-carboxyalkyloxy) benzyl …

A Rosowsky, RA Forsch…

Index: Rosowsky, Andre; Papoulis, Andrew T.; Forsch, Ronald A.; Queener, Sherry F. Journal of Medicinal Chemistry, 1999 ,  vol. 42,  # 6  p. 1007 - 1017

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Citation Number: 51

Abstract

A series of previously undescribed 2, 4-diamino-5-[2-methoxy-5-alkoxybenzyl] pyrimidines (3a-e) and 2, 4-diamino-5-[2-methoxy-5-(ω-carboxyalkyloxy) benzyl] pyrimidines (3f-k) with up to eight CH2 groups in the alkoxy or ω-carboxyalkyloxy side chain were synthesized ...