Synlett

Synthesis of both enantiomers of phenylglycine using (-)-sparteine

C Barberis, N Voyer

Index: Barberis, Claude; Voyer, Normand Synlett, 1999 ,  # 7  p. 1106 - 1108

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Citation Number: 6

Abstract

Abstract: The enantioselective synthesis of both enantiomers of the N-Moc phenylglycine derivatives is reported. The synthetic strategy shows the influence of N-protecting groups in the enantioselective deprotonation and carboxylation of N, N-protected benzylamine 1 using s-BuLi◊(-)-sparteine complex 4 as chirality source. Key words: enantioselective deprotonation,(-)-sparteine, carboxylation, silicon rearrangement, phenylglycine