Industrial synthesis of Maxacalcitol, the antihyperparathyroidism and antipsoriatic vitamin D3 analogue exhibiting low calcemic activity

…, K Shimizu, N Kubodera, T Mikami…

Index: Mikami, Tetsuhiro; Iwaoka, Tomoyasu; Kato, Masahiro; Watanabe, Hiroyoshi; Kubodera, Noboru Synthetic Communications, 1997 ,  vol. 27,  # 14  p. 2363 - 2369

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Citation Number: 19

Abstract

Maxacalcitol, the 22-oxa-derivative of 1α, 25-dihydroxyvitamin D3 and used currently as an antihyperparathyroidism and antipsoriatic drug, has been synthesized in seven chemical steps from 1α-hydroxydehydroepiandrosterone on the basis of our previously developed