An Efficient Approach to Azolyl??Substituted Steroids through Copper??Catalyzed Ullmann C–N Coupling

YN Kotovshchikov, GV Latyshev…

Index: Kotovshchikov, Yury N.; Latyshev, Gennadij V.; Lukashev, Nikolay V.; Beletskaya, Irina P. European Journal of Organic Chemistry, 2013 ,  # 34  p. 7823 - 7832

Full Text: HTML

Citation Number: 2

Abstract

Abstract Ullmann-type C–N coupling of vinyliodides and nitrogen heterocycles has been shown to be a straightforward and highly efficient approach to azolyl-substituted steroids. The amination reaction proved sensitive to steric effects exerted by the substituents in both iodide and heterocycle. The influence of reaction conditions (catalyst, base, solvent, and temperature) on conversion of the iodosteroid and the selectivity was investigated. The ...