synthesis and antibacterial activities of optically active ofloxacin and its fluoromethyl derivative.

…, S YOKOHAMA, KENI YAMAZAKI, KI SAKANO…

Index: Atarashi; Yokohama; Yamazaki; Sakano; Imamura; Hayakawa Chemical and pharmaceutical bulletin, 1987 ,  vol. 35,  # 5  p. 1896 - 1902

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Citation Number: 106

Abstract

Two optically active (100% enantiomeric excess) isomers (13a and 13b) of ofloxacin (1)[(±)- ofloxacin; DL-8280;(±)-9-fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H- pyrido [1, 2, 3-de][1, 4] benzoxazine-6-carboxylic acid] and their fluoromethyl derivatives (14a and 14b) were prepared via their optically active intermediates resolved by use of high- performance liquid chromatography (HPLC). The isomers (13a and 13b) were also ...