Synthesis of dibekacin (3', 4'-dideoxykanamycin B) from D-glucosamine and D-glucose.

M Yoshikawa, M Torihara, T Nakae, BC Cha…

Index: Yoshikawa; Torihara; Nakae; Cha; Kitagawa Chemical and pharmaceutical bulletin, 1987 ,  vol. 35,  # 5  p. 2136 - 2139

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Citation Number: 4

Abstract

An aminoglycoside antibiotic, dibekacin (= 3', 4'-dideoxykanamycin B)(22), has been synthesized from D-glucosamine and D-glucose using an oxidative decarboxylation reaction with lead tetraacetate and a reductive deacetoxylation reaction with sodium borohydride as keyreactions.