Forskolin derivatives. I. Synthesis, and cardiovascular and adenylate cyclase-stimulating activities of water-soluble forskolins.

…, K YAMASHITA, K ENOMOTO, A SHIOZAWA

Index: Tatee, Tochiro; Narita, Aya; Narita, Kazuhisa; Izumi, Giichi; Takahira, Takashi; Sakurai, Masao; Fujita, Akira; Hosono, Makoto; Yamashita, Kouwa; Enomoto, Keiko; Shiozawa, Akira Chemical and Pharmaceutical Bulletin, 1996 ,  vol. 44,  # 12  p. 2274 - 2279

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Citation Number: 9

Abstract

Water-soluble forskolin and 7-deacetylforskolin derivatives with an aminoacetyl, a 3- aminopropionyl, or a 4-aminobutyryl group at the 6-or 7-position were prepared, and their positive inotropic as well as vasodilative activities were evaluated in anesthetized dogs. 7- Deacetylforskolin (2) and 7-deacetyl-1-silylforskolin (6) were converted to the corresponding 7-chloroacylderivatives (3, 7, 10), which were reacted with amines to obtain 7-aminoacyl-7 ...